Clinical forms of canine visceral Leishmaniasis in naturally Leishmania infantum-infected dogs and related myelogram and hemogram changes
| Autor: | Maria das Graças Carvalho, Levi Eduardo Soares Reis, Rodolfo Cordeiro Giunchetti, Bruno Mendes Roatt, Denise da Silveira Lemos, Wendel Coura-Vital, Rodrigo Dian de Oliveira Aguiar-Soares, Cláudia Martins Carneiro, Roney de Carvalho Nicolato, Raquel Trópia de Abreu, Alexandre Barbosa Reis, Leoneide Érica Maduro Bouillet |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology Lymphocytosis Veterinary Microbiology lcsh:Medicine Monocytopenia Hematocrit Severity of Illness Index Bone Marrow Molecular Cell Biology Erythropoiesis Dog Diseases Leishmania infantum lcsh:Science Leishmaniasis Skin Multidisciplinary biology medicine.diagnostic_test Zoonotic Diseases Anemia Hematology Infectious Diseases medicine.anatomical_structure Veterinary Diseases Leishmaniasis Visceral Medicine Female medicine.symptom Research Article Veterinary Medicine medicine.medical_specialty Histology Immunology Veterinary Immunology Dogs Canine visceral leishmaniasis medicine Animals Biology business.industry lcsh:R Leukopenia biology.organism_classification medicine.disease Blood Cell Count Visceral leishmaniasis Asymptomatic Diseases Leukopoiesis Parasitology Veterinary Science lcsh:Q Bone marrow business Zoology |
| Zdroj: | PLoS ONE, Vol 8, Iss 12, p e82947 (2013) PLoS ONE Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| ISSN: | 1932-6203 |
| Popis: | Hematological analysis has limited applications for disease diagnosis in Leishmania infantum–infected dogs, but it can be very important in evaluating the clinical forms of the disease and in understanding the evolution of canine visceral leishmaniasis (CVL) pathogenesis. Recently, we demonstrated that alterations in leucopoiesis and erythropoiesis are related to clinical status and bone marrow parasite density in dogs naturally infected by L. infantum. To further characterize these alterations, we evaluated the association between the hematological parameters in bone marrow and peripheral blood alterations in groups of L. infantum–infected dogs: asymptomatic I (AD-I: serum negative/PCR+), asymptomatic II (AD-II: serum positive), oligosymptomatic (OD), and symptomatic (SD). Results were compared with those from noninfected dogs (NID). The SD group was found to present a decrease in erythropoietic lineage with concomitant reductions in erythrocytes, hemoglobin, and hematocrit parameters, resulting in anemia. The SD group also had increased neutrophils and precursors and decreased band eosinophils and eosinophils, leading to peripheral blood leucopenia. In the AD-II group, lymphocytosis occurred in both the peripheral blood and the bone marrow compartments. The SD group exhibited lymphocytosis in the bone marrow, with lymphopenia in the peripheral blood. In contrast, the AD-I group, showed no significant changes suggestive of CVL, presenting normal counts in bone marrow and peripheral blood. Our results showed for the first time that important changes in hematopoiesis and hematological parameters occur during ongoing CVL in naturally infected dogs, mainly in symptomatic disease. Taken together, our results based on myelogram and hemogram parameters enable better understanding of the pathogenesis of the anemia, lymphocytosis, and lymphopenia, as well as the leucopenia (eosinopenia and monocytopenia), that contribute to CVL prognosis. |
| Databáze: | OpenAIRE |
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