Asymptomatic subjects with zero coronary calcium score: coronary CT angiographic features of plaques in event-prone patients

Autor: Sang Il Choi, Kil Joong Kim, Jeong A. Kim, Min Su Lee, Eun Ju Chun, Jin Young Yoo
Rok vydání: 2013
Předmět:
Adult
Male
Acute coronary syndrome
medicine.medical_specialty
medicine.medical_treatment
Coronary Artery Disease
Coronary Angiography
Revascularization
Asymptomatic
Coronary artery disease
Predictive Value of Tests
Risk Factors
Internal medicine
Multidetector Computed Tomography
Republic of Korea
Odds Ratio
Prevalence
medicine
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Vascular Calcification
Cardiac imaging
Retrospective Studies
Chi-Square Distribution
business.industry
Middle Aged
Prognosis
medicine.disease
Coronary Vessels
Plaque
Atherosclerotic
Coronary Calcium Score
Stenosis
Logistic Models
Predictive value of tests
Asymptomatic Diseases
Multivariate Analysis
Disease Progression
cardiovascular system
Cardiology
Female
Radiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Zdroj: The International Journal of Cardiovascular Imaging. 29:29-36
ISSN: 1573-0743
1569-5794
Popis: The aims of this study were: (a) to assess clinical predictors and coronary computed tomography angiography (CCTA) characteristics of noncalcified coronary plaques (NCP) in subjects who had cardiac events despite a zero coronary artery calcium score (CACS), and (b) to describe computed tomography (CT) plaque characteristics in subjects with cardiac events. A total of 7,961 subjects with zero CACS were evaluated; 6,531 subjects underwent CCTA as part of a health check-up. Those who had zero CACS were included in our mid-term follow-up study. Cardiac events included cardiac death, acute coronary syndrome or revascularization with stable angina. More than one NCP was identified in 441 subjects with zero CACS, including 48 subjects with obstructive coronary artery disease (CAD) caused by NCPs. Age, male gender, hypertension, diabetes and low density lipoprotein were independent predictors of obstructive CAD. Among subjects with obstructive CAD, young adults were classified into low (79.2 %) or moderate (72.9 %) risk groups by the National Centers for Environmental Prediction III guidelines. Approximately 0.2 % of subjects had cardiac events during our follow-up period. All patients with cardiac events had NCPs with significantly lower mean CT numbers, higher remodeling indexes and worse degree of stenosis. In asymptomatic subjects with zero CACS, NCP was associated with cardiac events. CCTA might be useful for risk stratification among select populations with CAD and zero CACS who have certain plaque characteristics associated with cardiac events.
Databáze: OpenAIRE
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