The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

Autor: Weronika Dymara-Konopka, Marzena Laskowska
Jazyk: angličtina
Rok vydání: 2019
Předmět:
medicine.medical_specialty
Homocysteine
Endothelium
asymmetric dimethylarginine
Review
030204 cardiovascular system & hematology
Arginine
Catalysis
Nitric oxide
Preeclampsia
Inorganic Chemistry
Endothelial activation
lcsh:Chemistry
preeclampsia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pre-Eclampsia
nitric oxide
Pregnancy
Internal medicine
medicine
Humans
Disease process
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
reproductive and urinary physiology
030219 obstetrics & reproductive medicine
business.industry
Organic Chemistry
General Medicine
homocysteine
medicine.disease
female genital diseases and pregnancy complications
Computer Science Applications
Endocrinology
medicine.anatomical_structure
chemistry
lcsh:Biology (General)
lcsh:QD1-999
embryonic structures
Female
Asymmetric dimethylarginine
business
Perfusion
Signal Transduction
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2757 (2019)
ISSN: 1422-0067
Popis: Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications.
Databáze: OpenAIRE
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