Possible relationship between hydroxychloroquine and electrocardiographic and echocardiographic abnormalities in patients with inflammatory rheumatic diseases––a monocentric study

Autor: Filipe Oliveira Pinheiro, Miguel Martins Carvalho, Pedro Madureira, Maria Seabra Rato, Filipe Macedo, Lúcia Costa
Rok vydání: 2023
Předmět:
Zdroj: Lupus. 32:388-393
ISSN: 1477-0962
0961-2033
DOI: 10.1177/09612033221149875
Popis: Objective Hydroxychloroquine (HCQ) is used in the treatment of inflammatory rheumatic diseases and is considered a safe drug. The role of HCQ in the COVID-19 pandemic highlighted some deleterious cardiac effects of HCQ. We aim to evaluate the prevalence and development of cardiac-adverse events in HCQ-treated patients with inflammatory rheumatic diseases. Methods We performed a cross-sectional study where patients aged ≥18 years with a diagnosis of inflammatory rheumatic disease currently exposed or not to hydroxychloroquine underwent electrocardiogram (ECG) and echocardiogram. Comparisons between groups were evaluated using chi-square, t test, and Mann-Whitney U test. Logistic regression was performed to determine predictors of changes in ECG and echocardiography. Results Eighty patients were included, 75 (93.8%) female, aged 52 ± 13 years. ECG changes were seen in higher proportion in patients with hypertension (40.6% vs 12.5%, p = .004) and higher median potassium levels—4.5 (4.1–4.8) versus 4.2 (4.0–4.4), p = .023. Echocardiography changes were seen in older patients (59 ± 11 vs 50 ± 13 years, p = .003) and in patients with higher cumulative dose—1752 (785–2190) versus 438 (328–1022) g, p = 0.008 – and time of exposure to HCQ – 12 (6–15) versus 4 (2–9) years, p = 0.028. HCQ cumulative dose (OR 1.001, CI95% 1.000–1.002, p = .033) and exposure time (OR 1.136, CI95% 1.000–1.289, p = .049) were predictors of echocardiography changes, but when adjusted for age, neither HCQ cumulative dose nor exposure time were predictors of echocardiography changes. Conclusion No association was found between changes in ECG and echocardiogram in patients under HCQ, which remains a safe drug in patients with inflammatory rheumatic diseases.
Databáze: OpenAIRE
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