Pharmacokinetics of levobupivacaine following infant spinal anesthesia
| Autor: | Geoff Frawley, Andrew R. Bjorksten, Ben Hallett, Tony Velkov |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Anesthesia Spinal 03 medical and health sciences 0302 clinical medicine Pharmacokinetics 030202 anesthesiology Anesthesiology medicine Humans Anesthetics Local Levobupivacaine Bupivacaine Local anesthetic business.industry Ropivacaine Infant Apnea Surgery Anesthesiology and Pain Medicine Anesthesia Pediatrics Perinatology and Child Health Female medicine.symptom business 030217 neurology & neurosurgery Abdominal surgery medicine.drug |
| Zdroj: | Pediatric Anesthesia. 26:575-581 |
| ISSN: | 1155-5645 |
| DOI: | 10.1111/pan.12899 |
| Popis: | Summary Background Infant spinal anesthesia with levobupivacaine has been promoted as a technique to reduce both the risk of postoperative apnea and exposure to volatile anesthesia. There is, however, no pharmacokinetic data to support the currently recommended doses. Aims Our aim was to determine whether infant levobupivacaine spinal anesthesia is associated with plasma concentrations consistent with a low risk of local anesthetic systemic toxicity. Methods This was an open-label pharmacokinetic safety and tolerability study of levobupivacaine spinal anesthesia in infants |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|