Quantification of epicardial fat using 3D cine Dixon MRI
| Autor: | Martin Brundin, Carl-Johan Carlhäll, Frederica Viola, Tobias Scheffel, Carl Edin, Markus Henningsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male lcsh:Medical technology Magnetic Resonance Imaging Cine Cine MRI 030204 cardiovascular system & hematology Whole-heart imaging Proof of Concept Study 030218 nuclear medicine & medical imaging Coronary artery disease 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Interquartile range Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Observer Variation business.industry Significant difference Atrial fibrillation Dixon Epicardial fat Middle Aged medicine.disease lcsh:R855-855.5 Adipose Tissue Technical Advance Cardiovascular Diseases Epicardial adipose tissue Female Radiologi och bildbehandling Nuclear medicine business Pericardium Cardiac phase Radiology Nuclear Medicine and Medical Imaging |
| Zdroj: | BMC Medical Imaging BMC Medical Imaging, Vol 20, Iss 1, Pp 1-9 (2020) |
| Popis: | Background There is an increased interest in quantifying and characterizing epicardial fat which has been linked to various cardiovascular diseases such as coronary artery disease and atrial fibrillation. Recently, three-dimensional single-phase Dixon techniques have been used to depict the heart and to quantify the surrounding fat. The purpose of this study was to investigate the merits of a new high-resolution cine 3D Dixon technique for quantification of epicardial adipose tissue and compare it to single-phase 3D Dixon in patients with cardiovascular disease. Methods Fifteen patients referred for clinical CMR examination of known or suspected heart disease were scanned on a 1.5 T scanner using single-phase Dixon and cine Dixon. Epicardial fat was segmented by three readers and intra- and inter-observer variability was calculated per slice. Cine Dixon segmentation was performed in the same cardiac phase as single-phase Dixon. Subjective image quality assessment of water and fat images were performed by three readers using a 4-point Likert scale (1 = severe; 2 = significant; 3 = mild; 4 = no blurring of cardiac structures). Results Intra-observer variability was excellent for cine Dixon images (ICC = 0.96), and higher than single-phase Dixon (ICC = 0.92). Inter-observer variability was good for cine Dixon (ICC = 0.76) and moderate for single-phase Dixon (ICC = 0.63). The intra-observer measurement error (mean +/- standard deviation) per slice for cine was - 0.02 +/- 0.51 ml (- 0.08 +/- 0.4%), and for single-phase 0.39 +/- 0.72 ml (0.18 +/- 0.41%). Inter-observer measurement error for cine was 0.46 +/- 0.98 ml (0.11 +/- 0.46%) and for single-phase 0.42 +/- 1.53 ml (0.17 +/- 0.47%). Visual scoring of the water image yielded median of 2 (interquartile range = [Q3-Q1] 2-2) for cine and median of 3 (interquartile range = 3-2) for single-phase (P < 0.05) while no significant difference was found for the fat images, both techniques yielding a median of 3 and interquartile range of 3-2. Conclusion Cine Dixon can be used to quantify epicardial fat with lower intra- and inter-observer variability compared to standard single-phase Dixon. The time-resolved information provided by the cine acquisition appears to support the delineation of the epicardial adipose tissue depot. Funding Agencies|Swedish Medical Research CouncilSwedish Medical Research Council (SMRC) [2018-02779]; Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation [20170440]; County Council of Ostergotland [LIO-797721]; Swedish Research CouncilSwedish Research Council [2018-04164]; Linkoping University |
| Databáze: | OpenAIRE |
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