Effects of 6-methoxy-1,2,3,4-tetrahydro-β-carboline on the regional and subcellular distribution of serotonin in mouse and rat brains
| Autor: | William E. Askew, William M. McIsaac, Dorothy Taylor, Beng T. Ho |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Indoles Reserpine Pyridines Monoamine oxidase Hypothalamus Mice Inbred Strains Biology Tritium General Biochemistry Genetics and Molecular Biology 5-Hydroxytryptophan Mice Norepinephrine Thalamus Mesencephalon Cerebellum Pons Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Cerebral Cortex Medulla Oblongata Brain General Medicine Rat brain Stimulation Chemical Rats Subcellular distribution Endocrinology Pargyline Female Amine gas treating Protein Binding Subcellular Fractions medicine.drug |
| Zdroj: | Life Sciences. 11:493-502 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(72)90199-3 |
| Popis: | 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (6-MeO-THBC), which exerts its effect specifically on brain serotonin (5-HT), caused substantial increase of the amine in all the discrete areas of the rat brain. Since norepinephrine levels were unchanged, the increase in 5-HT was evidently not due to inhibition of monoamine oxidase activity. Subcellular distribution studies in mouse brain showed a significant increase in the particulate fraction of “bound” 5-HT by 6-MeO-THBC. The compound slowed the disappearance of intracisternally injected [ 3 H] 5-HT from the rat brain but had no effect on the level of [ 3 H] 5-hydroxyindoleacetic acid. Increased binding of the 5-HT was suggested as a possible mechanism for the effects of 6-MeO-THBC on brain 5-HT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|