3-D Ultrasound and Thyroid Cancer Diagnosis: A Prospective Study
| Autor: | Ghobad Azizi, Kele Piper, Kirk Faust, Lorna Ogden, Carl D. Malchoff, Laura Been, Michelle L. Mayo |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Acoustics and Ultrasonics Biophysics 030209 endocrinology & metabolism Sensitivity and Specificity Surgical pathology 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Positive predicative value Biopsy medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Thyroid Neoplasms Thyroid Nodule Prospective cohort study Thyroid cancer Aged Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Ultrasound Thyroid Middle Aged medicine.disease Fine-needle aspiration medicine.anatomical_structure Female 030211 gastroenterology & hepatology Radiology business |
| Zdroj: | Ultrasound in Medicine & Biology. 47:1299-1309 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2021.01.010 |
| Popis: | This study tests the hypothesis that evaluation of thyroid nodule (TN) margin irregularities by three-dimensional ultrasound (3-D-US) distinguishes benign from malignant TNs with greater sensitivity and specificity than two-dimensional ultrasound (2-D-US). We prospectively evaluated 344 TNs using both 2-D-US and 3-D-US followed by fine needle aspiration biopsy. TNs were divided into four groups based on the 3-D-US appearance of the margins. Bi-variate and multi-variate analyses were used. Surgical pathology confirmed 44 thyroid cancers in 40 patients. For 2-D-US, irregular margins and micro-calcifications (p < 0.001) were found more frequently in malignant TNs. Irregular margins on 2-D-US had a sensitivity and specificity of 61.4% and 79.3%, respectively. Irregular margins on 3-D-US had a sensitivity and specificity of 86.4% and 83.3%, respectively. Sensitivity, specificity, positive and negative predictive values were higher for irregular margins on 3-D-US than micro-calcifications and irregular margins on 2-D-US. Evaluation of TN margins by 3-D-US distinguished benign from malignant TNs with greater sensitivity and specificity than 2-D-US. |
| Databáze: | OpenAIRE |
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