Introgression of ASIP and TYRP1 Alleles Explains Coat Color Variation in Valais Goats
| Autor: | Ursula Herren, Alexandra Dubacher, Jan Henkel, Erika Bangerter, Tosso Leeb, P. Ammann, Cord Drögemüller, Christine Flury |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Coat DNA Copy Number Variations Genotype 0206 medical engineering Zoology Introgression 02 engineering and technology Gene flow 03 medical and health sciences Genetics Capra hircus Animals Allele Molecular Biology Alleles Genetics (clinical) biology Goats biology.organism_classification Breed White (mutation) Phenotype 030104 developmental biology Capra 020602 bioinformatics Biotechnology |
| Zdroj: | Journal of Heredity. 112:452-457 |
| ISSN: | 1465-7333 0022-1503 |
| DOI: | 10.1093/jhered/esab024 |
| Popis: | The Valais Blackneck goat is a Swiss goat breed with a characteristic coat color phenotype. Before the revision of the breed standard in 1938, 4 different color varieties of Valais goats were known. Besides Blackneck animals resembling the modern breed standard, the brown and white Copperneck goat, the white Capra Sempione, and the greyish Grüenochte comprised the historic Valais goats. The brown pigmentation of Copperneck goats had previously been traced back to an introgression of a mutant TYRP1 allele from Toggenburg goats. In the present study, we identified additional introgression events of distinct ASIP alleles causing the remaining 2 rare coat color patterns within the Valais Blackneck goat breed. We identified the introgression of the AWt allele from Appenzell or Saanen goats in white Capra Sempione goats. Similarly, introgression of the Apc allele from Peacock goats resulted in the greyish Grüenochte phenotype. These results demonstrate past hybridization events between breeds that are separated today. A perfect genotype-phenotype association in 393 Valais goats supported the causality of the genotyped variants for the different coat color phenotypes. Our study gives insights into the introgression of functionally relevant copy number variant (CNV) alleles controlling pigmentation between goat breeds with strikingly different coat color patterns. |
| Databáze: | OpenAIRE |
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