Nucleotide Sequence Analysis of the Enteropathogenic Escherichia coli Adherence Factor Plasmid pMAR7
| Autor: | Adam T. Boutin, Rogéria Keller, Valerie Burland, Debra J. Rose, Carl Brinkley, Frederick R. Blattner, Sara A. Klink, James B. Kaper |
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| Rok vydání: | 2006 |
| Předmět: |
Molecular Sequence Data
Immunology Virulence Molecular Genomics medicine.disease_cause Microbiology Bacterial Adhesion Pilus Plasmid Escherichia coli medicine Enteropathogenic Escherichia coli Gene Genetics Base Sequence biology Escherichia coli Proteins Nucleic acid sequence Sequence Analysis DNA biology.organism_classification Enterobacteriaceae Infectious Diseases Genes Bacterial Conjugation Genetic Fimbriae Bacterial Parasitology Fimbriae Proteins Plasmids |
| Zdroj: | Infection and Immunity. 74:5408-5413 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.01840-05 |
| Popis: | The complete nucleotide sequence was determined for pMAR7, an enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid that contains genes encoding a type IV attachment pilus (Bfp) and the global virulence regulator per . Prototypic EAF plasmid pMAR7 is self-transmissible, unlike the smaller EAF plasmid pB171, which has no genes encoding conjugative functions. The tra locus, a highly conserved 33-kb segment found in pMAR7, is similar to the tra (conjugation) region of the F plasmid. IS Ec13 copies flanking the pMAR7 tra region could potentially mobilize or delete the tra genes. Hybridization of 134 EPEC strains showed that a complete tra region is present only in strains of the EPEC1 clonal group. This study confirms EPEC's potential for dissemination of virulence attributes by horizontal transfer of the EAF plasmid. |
| Databáze: | OpenAIRE |
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