Relation between vascular endothelial markers and right ventricular function in the children with asthma
| Autor: | Hasan Yuksel, Münevver Yılmaz, Mecnun Cetin, Ozge Yilmaz, Bertan Karaboga, Şenol Coşkun |
|---|---|
| Přispěvatelé: | Celal Bayar University, Department of Pediatric Cardiology, Manisa, Turkey, Celal Bayar University, Department of Pediatrics, Manisa, Turkey, Celal Bayar University, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Exacerbation medicine.diagnostic_test Ventricular function business.industry Severe asthma Mild asthma 030204 cardiovascular system & hematology Doppler echocardiography medicine.disease Endothelin 1 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine Pediatrics Perinatology and Child Health Cardiology medicine Clinical severity business Asthma |
| Popis: | Objectives: The aim of the study was to evaluate the possible relationship of clinical severity during asthmatic exacerbation with the ventricular functions and the levels of vascular endothelial-related biomarkers endothelin-1 (ET-1) and platelet-derived growth factor-BB (PDGF-BB) in the condensed breathing air in the children with asthma. Methods: The study included a total of 80 children with acute asthmatic episode; of these, 28 had a mild, 26 had a moderate, and 26 had a severe attack. Samples of condensed breathing air were obtained for being analyzed for ET-1 and PDGF-BB levels during the study. All patients were evaluated by echocardiography at the beginning of the study and two weeks after the treatment of asthmatic episode. Results: Before treatment, mPAP in moderate and severe asthma groups was significantly higher than in mild asthma group (21.6 ± 7.3, 30.1 ± 9.8 and 32.7 ± 7.8; P < 0.01, P < 0.001, respectively). After treatment, no significant difference was detected between the asthma groups (P > 0.05). Am and Em waves, and IVRT, IVCT, ET and RV MPI during the asthmatic attack and after treatment did not change significantly between the groups; pre- and post-treatment values of these parameters also did not show significant differences. In exhaled air samples of the group with severe asthma exacerbation ET-1 and PDGF-BB were higher than those in the moderate and mild group (0.80 ± 0.42, 0.58 ± 0.30, 0.50 ± 0.15; P = 0.002 and 281.7 ± 253.2, 167.3 ± 148.1, 135.9 ± 74.9; P = 0.008 respectively). Conclusions: Ourstudy resultsshowedthatmPAPin direct proportion with the increasedinflammatory cytokineswassignificantly higher in asthma attacks and levels of ET-1 and PDGF-BB were significantly increased with severity of asthma, indicating a vascular response. © 2017, Iranian Journal of Pediatrics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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