[Results of curative chemoradiotherapy in patients with carcinomas of the anus]
| Autor: | Hana Tichá, Pavel Šlampa, Petr Pospíšil, Jana Gombošová |
|---|---|
| Jazyk: | čeština |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Anal Carcinoma Osteoradionecrosis Antineoplastic Agents Neutropenia medicine Anal cancer Humans Aged Aged 80 and over Leukopenia business.industry Radiotherapy Dosage Middle Aged medicine.disease Anus Anus Neoplasms Combined Modality Therapy Survival Analysis Acute toxicity Surgery medicine.anatomical_structure Treatment Outcome Oncology Chemotherapy Adjuvant Quality of Life Female Radiotherapy Adjuvant medicine.symptom business Chemoradiotherapy |
| Zdroj: | Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. 26(3) |
| ISSN: | 0862-495X |
| Popis: | BACKGROUND Anal carcinoma is a rare cancer. Surgical treatment is applied for small superficial tumors of the anal margin, the more advanced disease is treated with concomitant chemoradiotherapy. The aim of our study was to evaluate treatment outcomes in patients treated at the Masaryk Memorial Cancer Institute in 2006- 2010. PATIENTS AND METHODS We reviewed the clinical data of 29 newly diagnosed adult patients (aged 40- 84, average 60.7, median 60.6 years) treated between 2006- 2010. Demographic parameters, tumorrelated variables, toxicity of treatment, overall survival were analyzed. RESULTS Acute dermal toxicity G4 was observed in two patients, G3 in nine patients. Acute intestinal toxicity G4 was not observed in any patient, G3 in four patients. Acute urologic toxicity G3- 4 was not observed in any patient. Acute hematologic toxicity was observed: leukopenia G3/ G4 in 7/ 1 patients, neutropenia G3/ 4 in 9/ 4 patients, anemia G3/ 4 in no patient and thrombocytopenia G3/ 4 in 10/ 0 patients. Severe acute toxicity G3- 4 was observed more frequently in patients treated with concurrent chemoradiotherapy. Chronic dermal toxicity G2 was observed in two patients, G1 in four patients, chronic intestinal toxicity G1 was observed in four patients. One patient had urethral stenosis and three patients had stenosis of anus without invasive solutions. One patient had osteoradionecrosis of the left pubic bone. The 5 years overall survival of all patients was 76%. We failed to demonstrate improved survival due to the small and heterogeneous file in the group of patients in clinical stage I and II compared with patients with clinical stage III disease, or better survival in the group of patients who received concomitant chemoradiotherapy compared with patients treated only with radiotherapy. CONCLUSION Conservative treatment of locally advanced anal cancer is relatively well tolerated and safe treatment. Efficiency is comparable to surgical therapy, is also advantageous in terms of quality of life of patients due to the sphincter preservation. |
| Databáze: | OpenAIRE |
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