Isfahan Thyroid Cohort Study (ITCS)
| Autor: | Elham Faghih Imani, Atoosa Adibi, Awat Feizi, Mozhgan Karimifar, Samaneh Shahrokh Esfahani, Azamosadat Tabatabaei, Mehri Sirous, Rezvan Salehidoost, Ashraf Aminorroaya, Masoud Amini, Rokhsareh Meamar, Mohsen Janghorbani, Raheleh Sajad, Majid Abyar, Silva Hovsepian, Sima Aminorroaya Yamini, Aliye Tabatabaee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Goiter endocrine system diseases Population Hyperthyroidism Cohort Studies Hypothyroidism Thyroid peroxidase Internal medicine medicine Humans Euthyroid education Subclinical infection education.field_of_study biology business.industry Incidence (epidemiology) Thyroid General Medicine medicine.disease Thyroid Diseases medicine.anatomical_structure biology.protein Female Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives of Iranian medicine. 24(11) |
| ISSN: | 1735-3947 |
| Popis: | Background: The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status. Methods: This cohort is located in Isfahan, Iran. The first phase was initiated in 2006 with 2523 participants (1275 males, 1248 females). The participants were selected using multi-stage cluster sampling from the general residents of Isfahan, Iran. The study had two phases (2006 and 2011) and its third stage is planned for 2020–2021. Results: The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%–90%), overt hypothyroidism (2.8%, 95% CI: 2%‒3%), subclinical hypothyroidism (5.8%, 95% CI: 4%–6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%‒1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%–1%). Hypothyroidism and hyperthyroidism were significantly associated with goiter. The incidence of thyroid dysfunction was reported as follows: overt hypothyroidism (2.7, 95% CI: 1.6–3.7), subclinical hypothyroidism (20.6, 95% CI: 18–23), overt hyperthyroidism (1.9, 95% CI: 1–2.7) and subclinical hyperthyroidism (2.7, 95% CI: 1.6–3.7) per 1000 (person-year). Conclusion: We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection. |
| Databáze: | OpenAIRE |
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