The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage in rats
Autor: | Burcu Gül Baykalir, Pinar Tatli Seven, Huseyin Fatih Gul, Tuba Parlak Ak, Ismail Seven, Seda Iflazoglu Mutlu, Aslihan Arslan, Mine Yaman |
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Přispěvatelé: | Kepsut Meslek Yüksekokulu |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) CCL4 Oxidative phosphorylation Pharmacology Kidney digestive system Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Liver tissue medicine Animals Aspartate Aminotransferases Chrysin Carbon Tetrachloride Flavonoids Nutrition and Dietetics Plant Extracts Alanine Transaminase General Medicine digestive system diseases Rats Oxidative Stress 030104 developmental biology medicine.anatomical_structure Liver chemistry 030220 oncology & carcinogenesis Carbon tetrachloride |
Zdroj: | International Journal for Vitamin and Nutrition Research. 91:427-438 |
ISSN: | 1664-2821 0300-9831 |
Popis: | Arslan, Aslıhan Sur (Balikesir Author) The aim of this study was to investigate the possible protective effects of chrysin on oxidative status and histological alterations against carbon tetrachloride (CCl4)-induced liver and kidney tissue in rats. The animals were randomly divided into four groups; the control, chrysin (100 mg/kg), CCl4 (0.5 ml/kg) and chrysin + CCl4 groups. Liver and kidney injuries were assessed by biochemical and histopathological examinations. The levels of malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) activity were measured in tissues. Serum tumor necrosis factor-α (TNF-α), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine levels were also measured in blood samples. MDA, serum TNF-α, AST, ALT, urea, and creatinine levels (p < 0.05) were significantly higher, and SOD activity and GSH level were significantly (p < 0.05) lower in the CCl4 group than in the control group. Treatment with chrysin in the chrysin + CCl4 group decreased MDA, AST, ALT, creatinine, and TNF-α levels (p < 0.05), and increased SOD activity, GSH levels (p < 0.05), and serum TNF-α levels (p < 0.05). In addition, body weight change (BWC) (p < 0.05) and feed intake (FI) were significantly lower (p < 0.001) in the CCl4 group than in the control group. Moreover, treatment with chrysin increased BWC and FI in the chrysin + CCl4 group compared with that in the CCl4 group. These findings also confirmed by histopathological examination. The chrysin treatment ameliorated the CCl4-induced biochemical and pathological alterations. These results demonstrated that chrysin provided amelioration on the rat liver and kidney tissues CCl4-induced injury by increasing the antioxidant activity. |
Databáze: | OpenAIRE |
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