Hyperglycaemia and pharmacokinetics of rifampicin/isoniazid among TB-HIV co-infected patients in Kampala, Uganda
| Autor: | Joseph Musaazi, Barbara Castelnuovo, F Wyrsch, Bruno Ledergerber, S Haller, Andrew Kambugu, A von Braun, O Tschopp, Christine Sekaggya-Wiltshire, Jan Fehr |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Pulmonary and Respiratory Medicine medicine.medical_specialty endocrine system diseases HIV Infections Gastroenterology Pharmacokinetics Internal medicine Diabetes mellitus Isoniazid medicine Humans Uganda Retrospective Studies Coinfection business.industry Area under the curve nutritional and metabolic diseases Retrospective cohort study Fasting medicine.disease Impaired fasting glucose Infectious Diseases Hyperglycemia Cohort Rifampin business Rifampicin medicine.drug |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 24:1234-1240 |
| ISSN: | 1027-3719 |
| DOI: | 10.5588/ijtld.19.0755 |
| Popis: | OBJECTIVE: 1) To determine the prevalence of diabetes mellitus and impaired fasting glucose (IFG) in patients with TB and HIV co-infection, and 2) to investigate the effect of fasting plasma glucose (FPG) on rifampicin (RIF) and isoniazid (INH) serum concentrations.DESIGN: Retrospective data analysis of a cohort of HIV-infected adults with newly diagnosed pulmonary TB. Plasma glucose and TB drug levels were obtained at Week 0, 2, 8 and 24 of TB treatment.RESULTS: A total of 107 patients were included in this analysis. Random plasma glucose ≥200 mg/dL was found in 1/53 (2%) participant at Week 0. The prevalence of FPG ≥ 126 mg/dL decreased from 8/41 (20%) at Week 2 to 3/89 (3%) at Week 24. IFG (100–125 mg/dL) was observed in 23/41 (56%) participants at Week 2, and 39/89 (44%) at Week 24. FPG was inversely correlated with lower area under the curve (AUC0–24h) for RIF (c = -0.52; 95%CI -0.84 to -0.21; P = 0.001). FPG was not associated with lower INH AUC0–24h.CONCLUSION: We found a high prevalence of FPG ≥ 126 mg/dL, which decreased significantly during treatment, and a high proportion of IFG at the end of TB treatment. Higher FPG was associated with lower AUC for RIF. |
| Databáze: | OpenAIRE |
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