Periodic parasites and daily host rhythms
| Autor: | Kimberley F. Prior, Filipa Rijo-Ferreira, Patricia A. Assis, Ricardo T. Gazzinelli, Sarah E. Reece, Isabella C. Hirako, David R. Weaver |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
circadian rhythm
nutrient sensing Plasmodium Erythrocytes Circadian clock entrainment Nutrient sensing Mosquito Vectors Biology periodicity Microbiology Article Host-Parasite Interactions 03 medical and health sciences Mice 0302 clinical medicine Virology Circadian Clocks circadian clock Parasite hosting Animals Humans Parasites Circadian rhythm Gene 030304 developmental biology Inflammation 0303 health sciences Chronobiology Immunity intra-erythrocytic development cycle synchronicity inflammatory response Biological Evolution Circadian Rhythm Malaria fitness Multicellular organism host-parasite interactions plasmodium Evolutionary biology Parasitology Entrainment (chronobiology) metabolism 030217 neurology & neurosurgery |
| Zdroj: | Prior, K, Rijo-Ferreira, F, Assis, P A, Hirako, I C, Weaver, D R, Gazzinelli, R T & Reece, S 2020, ' Periodic parasites and daily host rhythms ', Cell Host & Microbe, vol. 27, no. 2, pp. 176-187 . https://doi.org/10.1016/j.chom.2020.01.005 Cell Host Microbe |
| DOI: | 10.1016/j.chom.2020.01.005 |
| Popis: | Biological rhythms appear to be an elegant solution to the challenge of coordinating activities with the consequences of the Earth's daily and seasonal rotation. The genes and molecular mechanisms underpinning circadian clocks in multicellular organisms are well understood. In contrast, the regulatory mechanisms and fitness consequences of biological rhythms exhibited by parasites remain mysterious. Here, we explore how periodicity in parasite traits is generated and why daily rhythms matter for parasite fitness. We focus on malaria (Plasmodium) parasites which exhibit developmental rhythms during replication in the mammalian host's blood and in transmission to vectors. Rhythmic in-host parasite replication is responsible for eliciting inflammatory responses, the severity of disease symptoms, and fueling transmission, as well as conferring tolerance to anti-parasite drugs. Thus, understanding both how and why the timing and synchrony of parasites are connected to the daily rhythms of hosts and vectors may make treatment more effective and less toxic to hosts. |
| Databáze: | OpenAIRE |
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