Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery
Autor: | Mohini A Shibu, Yacheng Luo, Jieru Yang, Mariusz Skwarczynskia, Istvan Toth |
---|---|
Rok vydání: | 2019 |
Předmět: |
medicine.medical_treatment
Cell Pharmaceutical Science Cell-Penetrating Peptides 02 engineering and technology antigen presenting cells Biology Cell-penetrating peptide antigen uptake Article 03 medical and health sciences Drug Delivery Systems Immune system adjuvant Antigen In vivo medicine Animals Humans Antigen-presenting cell 030304 developmental biology Vaccines 0303 health sciences Vaccine delivery vaccine delivery 021001 nanoscience & nanotechnology 3. Good health medicine.anatomical_structure humoral and cellular immunity Immune System Immunology 0210 nano-technology Adjuvant |
Zdroj: | Current Drug Delivery |
ISSN: | 1567-2018 |
Popis: | Subunit vaccines are composed of pathogen fragments that, on their own, are generally poorly immunogenic. Therefore, the incorporation of an immunostimulating agent, e.g. adjuvant, into vaccine formulation is required. However, there are only a limited number of licenced adjuvants and their immunostimulating ability is often limited, while their toxicity can be substantial. To overcome these problems, a variety of vaccine delivery systems have been proposed. Most of them are designed to improve the stability of antigen in vivo and its delivery into immune cells. Cell-penetrating peptides (CPPs) are especially attractive component of antigen delivery systems as they have been widely used to enhance drug transport into the cells. Fusing or co-delivery of antigen with CPPs can enhance antigen uptake, processing and presentation by antigen presenting cells (APCs), which are the fundamental steps in initiating an immune response. This review describes the different mechanisms of CPP intercellular uptake and various CPP-based vaccine delivery strategies. |
Databáze: | OpenAIRE |
Externí odkaz: |