Assessment of coronary artery disease during hospitalization for cancer treatment
| Autor: | Amir A. Mahabadi, Ulf Landmesser, Markus S. Anker, Ulrich Keller, Martin Schuler, Ria Ludwig, Sara Hadzibegovic, Fadi Al-Rashid, Stefan D. Anker, Alessia Lena, Tienush Rassaf, Raluca I. Mincu, Lena Hinrichs, Simone M. Mrotzek, Laura Johannsen, Lars Michel, Matthias Totzeck |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Acute coronary syndrome medicine.medical_specialty Time Factors medicine.medical_treatment Medizin Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Revascularization Risk Assessment Coronary artery disease 03 medical and health sciences 0302 clinical medicine Risk Factors Germany Neoplasms Internal medicine medicine Humans 030212 general & internal medicine Lung cancer Aged Retrospective Studies Cancer Original Paper business.industry General Medicine medicine.disease Combined Modality Therapy Cardiotoxicity Cardiac surgery Hospitalization Cardio-oncology Conventional PCI Cohort Cardiology Female Morbidity Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Clinical Research in Cardiology |
| Popis: | Background With improvement of cancer-specific survival, comorbidities and treatment-related side effects, particularly cardiovascular toxicities, need close attention. The aim of the present study was to evaluate clinical characteristics and outcomes of cancer patients requiring coronary angiography during inpatient care. Methods We performed a retrospective analysis of patients hospitalized between 02/2011 and 02/2018 in our two university hospital cancer centers. From a cohort of 60,676 cancer patients, we identified 153 patients (65.7 ± 11.6 years, 73.2% male), who underwent coronary angiography and were eligible for analysis. These were compared to a control group of 153 non-cancer patients pair-matched with respect to age, sex, and indication for catheterization. Results Cancer patients presented in 66% with an acute coronary syndrome (ACS). The most prevalent cancer entities were lymphoma (19%) and lung cancer (18.3%). The rate of primary percutaneous coronary interventions (PCI) was significantly lower in the cancer cohort (40.5% vs. 53.6%, p = 0.029), although manifestation of coronary artery disease (CAD) and PCI results were comparable (SYNergy between PCI with TAXus and cardiac surgery (SYNTAX)-score, delta pre- and post-PCI − 9.8 vs. − 8.0, p = 0.2). Mortality was remarkably high in cancer patients (1-year mortality 46% vs. 8% in non-cancer patients, p Conclusion Strategies to effectively control cardiovascular risks in cancer patients are needed. Additionally, suspected CAD in cancer patients should not prevent prompt diagnostic clarification and optimal revascularization as PCI results in cancer patients are comparable to non-cancer patients and occurrence of troponin-positive ACS leads to a significantly increased risk of mortality. Graphic Abstract |
| Databáze: | OpenAIRE |
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