Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China
| Autor: | Yu Zhang, Mengfan Yan, Xuejun Li, Anqi Shan, Hui Wu, Liwen Zhang, Baoxin Zhao, Yamin Liu, Ping Xian, Tong Wang, Xi Chen, Pengyi Guo, Naijun Tang, Chaokang Li, Guang-Hui Dong, Jie Chen, Yaoyan Li, Zhao Ma |
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| Rok vydání: | 2019 |
| Předmět: |
China
010501 environmental sciences 01 natural sciences Biochemistry Cohort Studies 03 medical and health sciences 0302 clinical medicine Environmental health Air Pollution Medicine Humans 030212 general & internal medicine Cities 0105 earth and related environmental sciences General Environmental Science Retrospective Studies Air Pollutants Proportional hazards model business.industry Incidence (epidemiology) Mortality rate Incidence Hazard ratio Type 2 Diabetes Mellitus Retrospective cohort study Environmental Exposure Europe Diabetes Mellitus Type 2 Cohort Particulate Matter business Cohort study |
| Zdroj: | Environmental research. 186 |
| ISSN: | 1096-0953 |
| Popis: | Background Ambient air pollution has recently been related to type 2 diabetes mellitus (T2DM), a disease that has caused an economic and health burden worldwide. Evidence of an association between air pollution and T2DM was reported in the United States and Europe. However, few studies have focused on the association with high levels of air pollutants in a developing country. Objectives We conducted a 12-year cohort study to assess the incidence and mortality of T2DM associated with long-term exposure to PM10, SO2, and NO2. Methods A retrospective cohort with participants from four cities in northern China was conducted to assess mortality and incidence of T2DM from 1998 to 2009. Incidence of T2DM was self-reported, and incident intake of an antidiabetic drug or injection of insulin simultaneously and mortality of T2DM was obtained from a family member and double checked against death certificates provided from the local center for disease control and prevention. Individual pollution exposures were the mean concentrations of pollutants estimated from the local environmental monitoring centers over the survival years. Hazard ratios (HRs) were estimated using Cox regression models after adjusting for potential confounding factors. Results A total of 39 054 participants were recruited into the mortality cohort, among which 59 subjects died from T2DM; 38 529 participants were analyzed in the incidence cohort, and 1213 developed new cases of T2DM. For each 10 μg/m3 increase in PM10, SO2, and NO2, the adjusted HRs and 95% confidence interval (CI) for diabetic incidence were 1.831 (1.778, 1.886), 1.287 (1.256, 1.318), and 1.472 (1.419, 1.528), respectively. Similar results can be observed in the analysis of diabetic mortality with HRs (95% CI) up to 2.260 (1.732, 2.950), 1.130 (1.042, 1.225), and 1.525 (1.280, 1.816), respectively. Conclusions Our results suggested that long-term exposure to high levels of PM10, SO2, and NO2 increase risk of incident and mortality of T2DM in China. |
| Databáze: | OpenAIRE |
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