Congenital Non-Neural Granular Cell Tumor Mimicking Nevus Lipomatosus Superficialis
| Autor: | Jun Yeong Park, Won Joo Kwon, Kwang Joong Kim, Bok Won Park, Kwang Ho Kim, Eun Joo Park, Eun Byul Cho |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Nevus lipomatosus superficialis Case Report Vimentin Dermatology Asymptomatic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Biopsy medicine CD68 Granular cell tumor Right forearm biology medicine.diagnostic_test business.industry medicine.disease 030220 oncology & carcinogenesis biology.protein Immunohistochemistry medicine.symptom business S100 proteins |
| Zdroj: | Annals of Dermatology |
| ISSN: | 2005-3894 1013-9087 |
| DOI: | 10.5021/ad.2017.29.6.776 |
| Popis: | A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 protein. Based on the pathologic findings, the patient was diagnosed as non-neural granular cell tumor (NN-GCT). GCT can be divided into conventional and non-neural GCT by immunoreactivity for S-100 protein. NN-GCT is typically manifested as a well-circumscribed, papulo-nodular dermal mass, and is known to occur in a younger group than does in conventional GCT, but is rare among children. To our knowledge, there have been no case reports of NN-GCT which appeared at birth and presented as grouped nodules. Therefore, we report this interesting case of congenital NN-GCT clinically mimicking NLS. |
| Databáze: | OpenAIRE |
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