Mechanisms of COVID-19 pathogenesis in diabetes

Autor:	Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Rok vydání:	2022
Předmět:	Inflammation SARS-CoV-2 Physiology Physiology (medical) Diabetes Mellitus COVID-19 Humans Receptors Virus Peptidyl-Dipeptidase A Cardiology and Cardiovascular Medicine
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 323:H403-H420
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.00204.2022
Popis:	Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is a global pandemic impacting 254 million people in 190 countries. Comorbidities, particularly cardiovascular disease, diabetes, and hypertension, increase the risk of infection and poor outcomes. SARS-CoV-2 enters host cells through the angiotensin-converting enzyme-2 receptor, generating inflammation and cytokine storm, often resulting in multiorgan failure. The mechanisms and effects of COVID-19 on patients with high-risk diabetes are not yet completely understood. In this review, we discuss the variety of coronaviruses, structure of SARS-CoV-2, mutations in SARS-CoV-2 spike proteins, receptors associated with viral host entry, and disease progression. Furthermore, we focus on possible mechanisms of SARS-CoV-2 in diabetes, leading to inflammation and heart failure. Finally, we discuss existing therapeutic approaches, unanswered questions, and future directions. Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/covid-19-and-diabetes/ .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53aaf3a475ff5662eee5b974965caf9e https://doi.org/10.1152/ajpheart.00204.2022 Zobrazit plný text záznamu