Homogeneously staining regions (HSR) in a human malignant melanoma
| Autor: | Santiago Besuschio, Alberto Andino Pavlovsky, Irma Slavutsky, Sonia Brieux de Salum |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Skin Neoplasms Clone (cell biology) Chromosome Disorders Trisomy Biology symbols.namesake Genetics medicine Humans Molecular Biology Melanoma Aged Chromosome Aberrations Chromosomes Human 6-12 and X Chromosomes Human 1-3 Chromosome Golgi apparatus medicine.disease Response to treatment Staining Cell culture Karyotyping Immunology symbols |
| Zdroj: | Cancer genetics and cytogenetics. 11(1) |
| ISSN: | 0165-4608 |
| Popis: | A case of nodular malignant melanoma (level V of Clark's classification) with homogeneously staining regions (HSR) on the long arm of one chromosome #2 is described. Ultrastructural observation of melanosomic and promelanosomic granules near Golgi's vesicles confirmed the histologic diagnosis. Chromosome analysis was performed on nine metaphases from a bone marrow sample and 76 metaphases from culture of the malignant skin tumor. G-banding revealed the presence of a clone with trisomy #8 and another cell line with the HSR marker. This is the first report of HSR in human melanoma cells. As HSR has been found only in malignant cells, we believe that among the many factors that influence the patients' clinical evolution and poor response to treatment, the genic imbalance is of the utmost importance. |
| Databáze: | OpenAIRE |
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