Determinants of cell type in patients with cancer of the lungs
| Autor: | Helen H. McDuffie, David J. Klaassen, James A. Dosman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Male medicine.medical_specialty Lung Neoplasms Adenocarcinoma Critical Care and Intensive Care Medicine Tobacco smoke Risk Factors Internal medicine medicine Carcinoma Humans Registries Risk factor Carcinoma Small Cell Lung cancer Aged Analysis of Variance business.industry Respiratory disease Smoking Cancer Middle Aged medicine.disease Saskatchewan Socioeconomic Factors Tumor progression Immunology Carcinoma Squamous Cell Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 98(5) |
| ISSN: | 0012-3692 |
| Popis: | In order to evaluate the determinants of cell type in patients with primary lung cancer, we compared smoking characteristics in 1,939 patients (1,474 men and 465 women). Patients with squamous cell carcinomas, adenocarcinomas, or small-cell carcinomas were eligible. This study did not consider smoking as a risk factor for lung cancer, as all subjects had a confirmed diagnosis. We were interested in smoking history and the pattern of smoking among those whose risk was 100 percent. Among these patients, we confirmed that a larger subset of nonsmoking individuals developed adenocarcinomas than squamous cell or small-cell carcinomas; however, the duration and intensity of cigarette smoking, as measured by pack-years, were not determinants of tumor cell type in male patients. Small-cell carcinomas in women were more strongly associated with cigarette smoking than either squamous cell carcinomas or adenocarcinomas. More than 3,500 different substances have been measured in tobacco smoke, including tumor initiators, promoters, and those involved in tumor progression. These data confirm the hypothesis that factors other than cigarette smoking are more likely to be involved in the initiation of adenocarcinomas than other cell types. Endogenous and exogenous factors related to gender may be more important than the duration or intensity of cigarette smoking. |
| Databáze: | OpenAIRE |
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