Association of a Chromosome Locus 9p21.3 CDKN2B-AS1 Variant rs4977574 with Hypertension: The TAMRISK Study
| Autor: | Seppo T. Nikkari, Tarja Kunnas, Jaakko Piesanen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Locus (genetics) Genome-wide association study 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Humans Medicine Genetic Predisposition to Disease Genetics (clinical) Genetic association business.industry Chromosome Mapping General Medicine Middle Aged medicine.disease 030104 developmental biology Genetic marker Case-Control Studies Hypertension Cohort Female RNA Long Noncoding Chromosomes Human Pair 9 business Variants of PCR |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 22:327-330 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2017.0249 |
| Popis: | Chromosome locus 9p21.3 CDKN2B antisense RNA 1 (CDKN2B-AS1) has been found to contain multiple genetic markers for coronary artery disease (CAD) by genome-wide association studies (GWAS). Of these, the association of variants rs4977574, rs10757274, and rs2383206 with hypertension was studied in the Tampere adult population cardiovascular risk study (TAMRISK).A Finnish cohort of 336 subjects diagnosed with hypertension and 444 controls was analyzed. Samples were genotyped for the CDKN2B-AS1 polymorphisms using Kompetitive Allele Specific PCR (KASP) or TaqMan techniques.Individuals with the minor genotype GG of rs4977574 had less hypertension compared to the other genotypes (p = 0.048, OR 1.58, 95% CI 1.01-2.48). The variants rs2383206 and rs10757274 were not associated with hypertension.Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|