Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity
| Autor: | Sergio Tufik, Juliana de Souza Apostólico, Alexandre C. Keller, Marcelo Pires Amaral, Edgar Ruz Fernandes, Daniela Santoro Rosa, Monica L. Andersen, Marcela Luize Barbosa, Silvia Beatriz Boscardin, Fernando Bandeira Sulczewski |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Host immunity Immunology Rapid eye movement sleep 02 engineering and technology Behavioral neuroscience Biology Article Behavioral Neuroscience 03 medical and health sciences Immune system medicine lcsh:Science Sleep disorder Multidisciplinary HIPOTÁLAMO Germinal center 021001 nanoscience & nanotechnology medicine.disease Natural resistance 030104 developmental biology lcsh:Q 0210 nano-technology Glucocorticoid medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP iScience, Vol 23, Iss 10, Pp 101599-(2020) iScience |
| ISSN: | 2589-0042 |
| DOI: | 10.1016/j.isci.2020.101599 |
| Popis: | Summary Although the influence of sleep quality on the immune system is well documented, the mechanisms behind its impact on natural host immunity remain unclear. Meanwhile, it has been suggested that neuroimmune interactions play an important role in this phenomenon. To evaluate the impact of stress-induced sleep disturbance on host immunity, we used a murine model of rapid eye movement sleep deprivation (RSD) integrated with a model of malaria blood-stage infection. We demonstrate that sleep disturbance compromises the differentiation of T follicular helper cells, increasing host susceptibility to the parasite. Chemical inhibition of glucocorticoid (Glcs) synthesis showed that abnormal Glcs production compromised the transcription of Tfh-associated genes resulting in impaired germinal center formation and humoral immune response. Our data demonstrate that RSD-induced abnormal activation of the hypothalamic-pituitary-adrenal axis drives host susceptibility to infection. Understanding the impact of sleep quality in natural resistance to infection may provide insights for disease management. Graphical Abstract Highlights • REM sleep deprivation (RSD) worsens malaria induced by Plasmodium yoelii infection • RSD decreases germinal center formation and impairs specific antibody production • Exacerbated glucocorticoid production impairs T lymphocyte differentiation • The relationship between sleep and immunity is a target for malaria management Behavioral Neuroscience; Immunology |
| Databáze: | OpenAIRE |
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