Plasma esterases and inflammation in ageing and frailty
| Autor: | Ken W. Woodhouse, Brian L. Calver, M Sinead O'Mahony, Ruth E. Hubbard |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Senescence Aging medicine.medical_specialty Necrosis Frail Elderly Inflammation Biology Esterase Internal medicine Blood plasma medicine Humans Pharmacology (medical) Butyrylcholinesterase Aged 80 and over Pharmacology Esterases Case-control study General Medicine Endocrinology Ageing Case-Control Studies Acetylcholinesterase Female medicine.symptom Carboxylic Ester Hydrolases Biomarkers |
| Zdroj: | European Journal of Clinical Pharmacology. 64:895-900 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-008-0499-1 |
| Popis: | Esterases are enzymes of drug metabolism known to be reduced in frail older people and during acute illness. The mechanism for this is unknown. The aim of this study was to examine esterase activity and inflammation in ageing and frailty. Thirty frail patients (mean age 84.9 years) dependent on continuing inpatient care, 40 patients of intermediate frailty attending Day Hospital (84.2 years), 40 fit older controls (82.7 years) and 30 young controls (23.3 years) were studied. Frailty indicators, plasma esterase activities and markers of inflammation were measured. With increasing patient frailty, C-reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) increased significantly and esterase activity, with the exception of aspirin esterase, fell significantly (p |
| Databáze: | OpenAIRE |
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