A comparative study of the spectral, fluorometric properties and photostability of natural curcumin, iron- and boron- complexed curcumin
| Autor: | Fatima Mohammed, Seamas Cassidy, Fryad Z. Henari, Fiza Rashid-Doubell |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Curcumin
Photolysis Absorption spectroscopy 010405 organic chemistry Chemistry Polarity (physics) Iron Quantum yield 010402 general chemistry Photochemistry 01 natural sciences Fluorescence Atomic and Molecular Physics and Optics Fluorescence spectroscopy 0104 chemical sciences Analytical Chemistry Solvent chemistry.chemical_compound Spectrometry Fluorescence Drug Stability Spectroscopy Instrumentation Boron |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 183 |
| ISSN: | 1873-3557 |
| Popis: | Curcumin is a yellow phenolic compound with a wide range of reported biological effects. However, two main obstacles hinder the use of curcumin therapeutically, namely its poor bioavailability and photostability. We have synthesized two curcumin complexes, the first a boron curcumin complex (B-Cur2) and the second an iron (Fe-Cur3) complex of curcumin. Both derivatives showed high fluorescence efficiency (quantum yield) and greater photostability in solution. The improved photostability could be attributed to the coordination structures and the removal of β-diketone group from curcumin. The fluorescence and ultra violet/visible absorption spectra of curcumin, B-Cur2 and Fe-Cur3 all have a similar spectral pattern when dissolved in the same organic solvent. However, a shift towards a lower wavelength was observed when moving from polar to non-polar solvents, possibly due to differences in solvent polarity. A plot of Stokes' shift vs the orientation polarity parameter (Δf) or vs the solvent polarity parameter (ET 30) showed an improved correlation between the solvent polarity parameter than with the orientation polarity parameter and indicating that the red shift observed could be due to hydrogen-bonding between the solvent molecules. A similar association was obtained when Stokes' shift was replaced by maximum synchronous fluorescence. Both B-Cur2 and Fe-Cur3 had larger quantum yields than curcumin, suggesting they may be good candidates for medical imaging and in vitro studies. |
| Databáze: | OpenAIRE |
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