Non-invasive imaging techniques for the
| Autor: | Cristina Violeta Tutunaru, Caruntu Constantin, Sabina Zurac, Simona Roxana Georgescu, Daniel Boda, Mircea Tampa, Nicolae Gabriel Ianoşi, Alexandra Batani, Daniela Calina, Mihaela Ilie, Simona Laura Ianoși, Daniela Neagoe |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Reflectance confocal microscopy Cancer Research medicine.medical_specialty Noninvasive imaging diagnosis non-invasive reflectance confocal microscopy Bowen's disease 03 medical and health sciences 0302 clinical medicine In vivo medicine Alternative methods medicine.diagnostic_test business.industry Large cell Articles medicine.disease Dermatology in vivo 030104 developmental biology Oncology 030220 oncology & carcinogenesis Skin biopsy Skin cancer dermoscopy business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | Bowen's disease (BD) is a relatively frequent non-melanoma skin cancer occurring mostly in elderly people. Until now, the usual way to establish the diagnosis is histopathological examination of a skin biopsy. Dermoscopy and reflectance confocal microscopy (RCM) are modern alternative methods that can be used as quick and non-invasive diagnostic techniques and as follow-up instruments in cases in which a conservative treatment is chosen for the management of BD. There are no very specific dermoscopic criteria for the diagnosis of this disease, but some dermoscopic features (scaly surface, vascular structures and pigmentation) can be found more frequent and can be helpful for the diagnosis. RCM of BD shows an acanthotic epidermis with two types of targetoid cells: the first, a large cell with bright center and dark peripheral halo, the second, a cell with dark center and a bright rim surrounded by a dark hallo, related with dyskeratotic cells on histological examination. BD management could be improved by using non-invasive, in vivo imaging techniques that allow a fast and easy diagnosis and can be used as follow-up tools. However, larger studies are necessary for the validation of our observations. |
| Databáze: | OpenAIRE |
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