Brain mitochondrial oxidative metabolism during and after cerebral hypoxia–ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy
| Autor: | Ernest B. Cady, Kevin D. Broad, Ilias Tachtsidis, Xavier Golay, Esther Baer, Nicola J. Robertson, Alan Bainbridge, D Price, Stuart Faulkner, David L. Thomas, Tingting Zhu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
MRS Magnetic Resonance Spectroscopy Swine viruses Cognitive Neuroscience Metabolite chemistry.chemical_element Review Mitochondrion Cytochrome-c-oxidase chemistry.chemical_compound Nuclear magnetic resonance medicine Animals Cytochrome c oxidase Spectroscopy Spectroscopy Near-Infrared medicine.diagnostic_test biology Chemistry Phosphorus Phosphorus Isotopes Magnetic resonance imaging Nuclear magnetic resonance spectroscopy 31P Hypoxia–ischemia Mitochondria NIRS Neurology Hypoxia-Ischemia Brain biology.protein Oxidation-Reduction |
| Zdroj: | Neuroimage |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2013.08.016 |
| Popis: | Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient cerebral hypoxia–ischemia (HI) in the newborn piglet. Methods Twenty-four piglets (aged Highlights • 31P MRS correlated with broadband NIRS during and after transient hypoxia–ischemia. • A double-linear model best describes NTP/epp vs Δ[oxCCO] during HI. • Threshold point in double-linear model interpreted as cessation of ATP manufacture. • Poor outcome correlates with weaker recovery of both 31P MRS ratios and Δ[oxCCO]. • Mitochondrial dysfunction may be the cause of reduction of Δ[oxCCO]. |
| Databáze: | OpenAIRE |
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