Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality

Autor:	David Macias-Verde, Javier Burgos-Burgos, Pedro C. Lara
Rok vydání:	2020
Předmět:	0301 basic medicine ARDS CO Carbon monoxide Inflammasomes Air Microbiology Na+ K+-ATPase Sodium-potassium adenosine triphosphatase MERS Middle east respiratory syndrome DAMP Damage-associated molecular pattern DNA Deoxyribonucleic acid 0302 clinical medicine Sv Sievert TSNA Tobacco-specific nitrosamines Air Pollution Radioactive PAMP Pathogen-associated molecular pattern SO2 Sulfur dioxide µSv microSievert media_common education.field_of_study IFN-γ Interferon-gamma TNF-α Tumor necrosis factor-alpha Inflammasome General Medicine GSDMD Gasdermin D Pollution CO2 Carbon dioxide TGF-β Transforming growth factor beta Causality Radioactivity medicine.symptom K+ Potassium ion Alzheimer’s disease medicine.drug NO2 Nitrogen dioxide media_common.quotation_subject Climate Change Indoor bioaerosol Population Inflammation AD Alzheimer’s disease Models Biological COVID-19 Coronavirus disease-2019 Article WHO World Health Organization mSv miliSievert 03 medical and health sciences USEPA United States Environmental Protection Agency ACE-2 Angiotensin-converting enzyme-2 Environmental health NLR Family Pyrin Domain-Containing 3 Protein ARDS Acute respiratory distress syndrome medicine Humans PM10 Particulate matter with diameter <10 µm SARS-COV-2 Severe acute respiratory syndrome coronavirus-2 Particle Size education Pandemics Neuroinflammation Aerosols THP-1 Tamm-Horsfall Protein-1 TLR Toll like receptor business.industry SARS-CoV-2 Ca2+ Calcium ion COVID-19 NF-κB Nuclear factor-kappa B Pneumonia medicine.disease HSPCs Hematopoietic stem/progenitor cells NLRP3 inflammasome oAβ Oligomeric amyloid beta 030104 developmental biology NLRP3 Nucleotide binding domain and repeated inflammation of leucine-rich protein 3 PM2.5 Particulate matter with diameter < 2.5 µm mBq miliBecquerel ORF Open reading frame Particulate Matter Nervous System Diseases business 030217 neurology & neurosurgery AT1 angiotensin II receptor type 1 ROS Reactive oxygen species
Zdroj:	Medical Hypotheses
ISSN:	1532-2777
Popis:	We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5329952881526d3affe4880692c7a641 https://pubmed.ncbi.nlm.nih.gov/33243665 Zobrazit plný text záznamu Full Text from ScienceDirect