Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey
Autor: | Turhan Nk, Yucel Ustundag, Sevil Uygun Ilikhan, Ayse C. Hamamcioglu, Ahmet Dursun, Firuzan Kokturk |
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Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
Rok vydání: | 2015 |
Předmět: |
Adult
Liver Cirrhosis Male Alcoholic liver disease medicine.medical_specialty Turkey Biopsy Liver fibrosis Autoimmune hepatitis Comorbidity Peptidyl-Dipeptidase A Gastroenterology Turkish population Young Adult Primary biliary cirrhosis INDEL Mutation Fibrosis Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Genetic Association Studies Aged Aged 80 and over Polymorphism Genetic biology business.industry Gene polymorphism Angiotensin-converting enzyme General Medicine Middle Aged medicine.disease biology.protein Female Steatohepatitis business |
Zdroj: | Genetics and molecular research : GMR. 14(4) |
ISSN: | 1676-5680 |
Popis: | Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibrosis has been demonstrated in rat studies, the results of clinical studies area have been contradictory. The aim of this study was to assess the possible association between ACE gene I/D polymorphism and liver fibrosis in a large group of Turkish patients from the western Black Sea region. In 418 patients with different etiologies, ACE gene I/D polymorphism and serum ACE levels were investigated. The distribution of the “DD”, “ID”, “II” genotypes of the ACE gene were 32.5, 48.8, and 18.7% in the mild to moderate fibrosis group (N = 246, F:1-3 according to Ishak’s score) and 39.0, 44.2, and 16.9% in the advanced fibrosis group (N = 172, F:4-6 according to Ishak’s score). A significant correlation between serum ACE levels and ACE gene alleles was identified (P < 0.001): serum ACE levels of patients with D alleles were higher than those of patients with I alleles [44 (min 7-max 101) versus 29 (min 7-max 96)]. Patients with advanced fibrosis were also found to be older than those with mild to moderate fibrosis (P < 0.001). No significant association was noted between the patient gender and fibrosis severity. We conclude that ACE I/D polymorphism is not associated with the degree of liver fibrosis. © FUNPEC-RP. |
Databáze: | OpenAIRE |
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