Impact of dosimetric parameters on local control for patients treated with three-dimensional pulsed dose-rate brachytherapy for cervical cancer
| Autor: | Claude Krzisch, Didier Peiffert, Sabrina Boyrie, Valentin Harter, Martine Delannes, Xavier Montbarbon, Claire Charra-Brunaud, Isabelle Barillot, Anne Ducassou, Philippe Lang, Marie-Hélène Baron, Youlia M. Kirova |
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| Přispěvatelé: | Institut Claudius Regaud, Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Département de radiothérapie oncologique [Paris], Institut Curie [Paris], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), CHU Amiens-Picardie, Service d'Oncologie Radiothérapie [CHU Pitié Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Radiothérapie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Léon Bérard [Lyon], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), CRLCC Institut Claudius Regaud, Institut de Cancérologie de Lorraine - Alexis Vautrin (ICL), Institut Curie, Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), Hôpital Universitaire d'Amiens, Service de Radiothérapie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Service de radiothérapie (CHRU Besançon), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_treatment
Brachytherapy Planning target volume Uterine Cervical Neoplasms MESH: Magnetic Resonance Imaging MESH: Aged 80 and over Risk Factors MESH: Risk Factors Prospective Studies Prospective cohort study MESH: Radiotherapy Dosage MESH: Treatment Outcome Cervical cancer Aged 80 and over MESH: Aged MESH: Middle Aged medicine.diagnostic_test Radiotherapy Dosage MESH: Carcinoma Squamous Cell MESH: Follow-Up Studies Middle Aged Magnetic Resonance Imaging 3. Good health MESH: Uterine Cervical Neoplasms Treatment Outcome Oncology MESH: Survival Analysis Carcinoma Squamous Cell Female MESH: Tomography X-Ray Computed MESH: Brachytherapy MESH: Neoplasm Recurrence Local Adult MESH: Imaging Three-Dimensional Adenocarcinoma Kerma Imaging Three-Dimensional MESH: Dose-Response Relationship Radiation medicine Humans Radiology Nuclear Medicine and imaging Pulsed-Dose Rate Brachytherapy External beam radiotherapy Aged Pulsed dose-rate brachytherapy MESH: Humans business.industry MESH: Adenocarcinoma Magnetic resonance imaging Dose-Response Relationship Radiation MESH: Adult medicine.disease Survival Analysis MESH: Prospective Studies Three-dimensional brachytherapy Local control [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Neoplasm Recurrence Local business Nuclear medicine Tomography X-Ray Computed MESH: Female Follow-Up Studies |
| Zdroj: | Brachytherapy Brachytherapy, Elsevier, 2014, 13 (4), pp.326-331. ⟨10.1016/j.brachy.2014.03.003⟩ |
| ISSN: | 1538-4721 |
| DOI: | 10.1016/j.brachy.2014.03.003⟩ |
| Popis: | International audience; To investigate the impact of dose-volume histograms parameters on local control of three-dimensional (3D) image-based pulsed dose-rate brachytherapy (BT).METHODS AND MATERIALS:Within a French multicentric prospective study, the data of the 110 patients treated for cervical cancer with external beam radiotherapy followed by 3D image-based and optimized pulsed dose-rate BT were analyzed. Delineation procedures were performed on magnetic resonance imaging in a minority of cases and on CT for the majority of cases, adapted from the Gynaecological Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology recommendations. Optimization procedure was left to the discretion of the treating center.RESULTS:At 2 years, local control rate reached 78%. Dose to Point A, total reference air kerma, and intermediate-risk clinical target volume (IR-CTV) V60 were predictive factors for local control (p = 0.001, p = 0.001, and p = 0.013, respectively). Patients with IR-CTV V60 |
| Databáze: | OpenAIRE |
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