Pharmacological screening and acute toxicity of bark roots of Guettarda platypoda
| Autor: | Silene Carneiro do Nascimento, Luiz Alberto Lira Soares, Haroudo Satiro Xavier, Gardenia C.G. Militão, Teresinha Gonçalves da Silva, Ivone Antônia de Souza, Sebastião J. de Melo, Fernando Wesley Cavalcanti de Araújo, Evelyn M. L. Pina, Isla V. G. A. Bastos |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
medicine.medical_treatment lcsh:RS1-441 Pharmacology acute toxicity Guettarda platypoda lcsh:Pharmacy and materia medica medicine antitumor activity General Pharmacology Toxicology and Pharmaceutics Cytotoxicity anti-inflammatory activity Rubiaceae biology business.industry biology.organism_classification Acute toxicity Phytochemical visual_art Toxicity visual_art.visual_art_medium cytotoxicity Bark business |
| Zdroj: | Revista Brasileira de Farmacognosia, Volume: 22, Issue: 6, Pages: 1315-1322, Published: 09 OCT 2012 Revista Brasileira de Farmacognosia, Vol 22, Iss 6, Pp 1315-1322 (2012) Revista Brasileira de Farmacognosia v.22 n.6 2012 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| Popis: | Due to its folk use, scientific reports and phytochemical screening, the purpose of this work was to study the phytochemical and the biological properties of the methanol extract and to evaluate the anti-inflammatory activity as well as determine the acute toxicity, antitumor and cytotoxic activity of the root barks of Guettarda platypoda DC., Rubiaceae. In this analysis the presence of flavonoids and therpenoids were identified. These data and the ones in the literature indicated it as a potential antioxidant and motivated the cytotoxic analysis related with three tumoral cell strains as well as to evaluate its antitumoral activity (sarcoma 180 and Ehrlich carcinoma) in female mice. Due to the presence of esteroids and the previous study of the ethanolic extract, its anti-inflammatory activity and toxicity were also evaluated. Absence or low toxicity in 2000 mg/kg doses was verified and the attention to their phytochemical and pharmacological properties is constantly increasing. |
| Databáze: | OpenAIRE |
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