Ocular distribution of lomefloxacin 0.3% after a single instillation in the infected eye of pigmented rabbits
| Autor: | Arthur Jauch, P.P. Elena |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Administration Topical Cmax Biological Availability Quinolones Eye Infections Bacterial Cornea Pharmacokinetics Anti-Infective Agents Ophthalmology medicine Animals Pharmacology (medical) Pseudomonas Infections Iris (anatomy) Antibacterial agent Pharmacology business.industry Area under the curve Eye drop eye diseases medicine.anatomical_structure Anesthesia Area Under Curve Lomefloxacin sense organs Rabbits business medicine.drug Fluoroquinolones |
| Zdroj: | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 13(6) |
| ISSN: | 1080-7683 |
| Popis: | We investigated the distribution of lomefloxacin, a fluoroquinolone, in the infected eye of pigmented rabbits after one instillation of 50 microliters lomefloxacin 0.3% eye drop, and compared tissue concentrations with therapeutic levels. Infection was induced by 6 instillations of Pseudomonas aeruginosa inoculum 6 x 10(5) bacteria) on centrally scratched cornea of 32 pigmented rabbits. Fifty microliters of 14[C] lomefloxacin 0.3% were instilled 24 hours after infection and animals were sacrificed 0.25, 0.5, 1, 2, 4, 8 and 12 hours later. Ocular structures, tear fluid, whole blood and plasma were then sampled, and tissue levels over time, Tmax, Cmax and area under the curve (AUC) were calculated. Lomefloxacin rapidly penetrated into the ocular structures: tear (Tmax 0.25 hours, Cmax 366 micrograms/ml, AUC 360 micrograms/ml x hour), corresponding value were for: eye lids (0.25, 7, 33), conjunctiva (0.25, 11, 7), cornea (0.25, 56, 70), aqueous humor (1, 8, 14), iris ciliary-body (4, 34, 252), lens (1, 0.2, 0.6). Tear levels remained high for many hours and were 34, 48, 1 and 27 micrograms/ml at 1, 2, 4 and 8 hours following a single instillation. Elimination from ocular structures was rapid. Therapeutic levels were achieved after a single instillation (mainly in the external ocular structures) when compared with MIC 90% values (1-10 micrograms/ml). |
| Databáze: | OpenAIRE |
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