Higher prepubertal IGF-1 concentrations associate to earlier pubertal tempo in both sexes

Autor:	Ingrid Baier, Ana Pereira, Pedro Ferrer, German Iñiguez, Verónica Mericq
Rok vydání:	2022
Předmět:	Endocrinology Endocrinology Diabetes and Metabolism Pediatrics Perinatology and Child Health
Zdroj:	Hormone Research in Paediatrics.
ISSN:	1663-2826 1663-2818
DOI:	10.1159/000528662
Popis:	Introduction: Pubertal onset is triggered by multiple neuroendocrine interactions. The role of prepubertal IGF-1 in this process has not been explored in both sexes. Our objective is to analyze the association of prepubertal IGF-1 concentration with age at thelarche (B2) and menarche (M) in girls and age at gonadarche (G2) in boys. Methods: Longitudinal study (n=1196 boys and girls) within the Growth and Obesity Chilean cohort Study (GOCS). At ages ≈ 6.7 years blood sample for IGF-1. Subjects analyzed into 4 groups according to the onset age of the pubertal event. Results: Higher prepubertal IGF-1 levels were observed at earlier ages of thelarche (p=0.003) and menarche onset (p=0.041). A taller prepubertal height was observed at younger ages of thelarche and menarche (p=
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d824b1d9ae83393d54b598bacab174 https://doi.org/10.1159/000528662 Zobrazit plný text záznamu