A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations
| Autor: | D. Chmelevsky, R. Guttenberger, Johann Kummermehr, Albrecht M. Kellerer |
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| Rok vydání: | 1991 |
| Předmět: |
Mice
Inbred C3H Radiological and Ultrasound Technology Analytical expressions Fibrosarcoma Numerical analysis Melanoma Experimental Nonparametric statistics Dose dependence Mammary Neoplasms Experimental Radiotherapy Dosage Neoplasms Experimental Common method Growth curve (statistics) Plot (graphics) Mice Animals Applied mathematics Radiology Nuclear Medicine and imaging Neoplasm Transplantation Cell survival Mathematics |
| Zdroj: | International Journal of Radiation Biology. 59:1253-1268 |
| ISSN: | 1362-3095 0955-3002 |
| DOI: | 10.1080/09553009114551121 |
| Popis: | Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence. The analysis is employed to derive the alpha/beta ratios of the linear-quadratic dose dependence, and different methods have been developed for this purpose. A common method uses the so-called Fe plot. A more complex but also more rigorous method has been introduced by Lam et al. (1979). Their method, which is based on numerical optimization procedures, is generalized and somewhat simplified in the present study. Tumour-regrowth data are used to explain the nonparametric procedure which provides alpha/beta ratios without the need to postulate analytical expressions for the relationship between cell survival and regrowth delay. |
| Databáze: | OpenAIRE |
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