| Autor: |
Alex H. Y. Chan, Terence C. S. Ho, Kwasi Agyei-Owusu, Finian J. Leeper |
| Přispěvatelé: |
Leeper, Finian [0000-0003-3408-5199], Apollo - University of Cambridge Repository |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Organicbiomolecular chemistry. 20(45) |
| ISSN: |
1477-0539 |
| Popis: |
Inhibition of thiamine pyrophosphate (TPP)-dependent enzymes with thiamine/TPP analogues that have the central thiazolium ring replaced with other rings is well established, but a limited number of central rings have been reported. We report a novel analogue, pyrrothiamine, with a central pyrrole ring. We further develop pyrrothiamine derivatives as potent and selective inhibitors of pyruvate dehydrogenase, which might have anti-cancer potential. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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