Comparative genomic hybridization analysis of transitional cell carcinomas of the renal pelvis
| Autor: | Marta Bernués, María Rosa Caballín, Carme Casadevall, M A Rigola, J. Egozcue, Rosa Miró, Antoni Gelabert, Carme Fuster |
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| Rok vydání: | 2001 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Pathology Chromosome Disorders Biology DNA sequencing Cytogenetics Chromosome regions Internal medicine Genetics medicine Image Processing Computer-Assisted Humans Kidney Pelvis Molecular Biology In Situ Hybridization Fluorescence Aged Neoplasm Staging Aged 80 and over Chromosome Aberrations Carcinoma Transitional Cell Chromosome Nucleic Acid Hybridization Middle Aged medicine.disease Primary tumor Kidney Neoplasms Transitional cell carcinoma Endocrinology medicine.anatomical_structure Transitional Cell Female Renal pelvis Comparative genomic hybridization |
| Zdroj: | ResearcherID |
| ISSN: | 0165-4608 |
| Popis: | We used comparative genomic hybridization to analyze 10 primary tumor samples from patients with transitional cell carcinoma of the renal pelvis. The most frequent loss was located at 9q, that is, in 50% of the tumors. Gains of DNA sequences were most frequently observed in chromosome regions 1q21 approximately q23, 2p23 approximately p25, 8q21.1 approximately q22 and in the whole chromosome 20. High level amplifications at 1q21 approximately q25, 6p22 approximately p23, 8q21 approximately q22, 8q22 approximately q24.1, 11q13, and 12q14 approximately q21 were detected. Most of these regions have previously been reported to be involved in transitional cell carcinoma of the bladder, thus confirming the importance of an increasing number of chromosome imbalances in the development and progression of this type of tumors. |
| Databáze: | OpenAIRE |
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