Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling
| Autor: | Tue Smith Jørgensen, Lasse Gliemann, Peter Piil, Michael Nyberg, Rasmus Damsgaard, Jon Egelund, Ylva Hellsten |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences Cyclic gmp 0302 clinical medicine Physical medicine and rehabilitation Physiology (medical) Internal medicine medicine Humans Muscle Skeletal Cyclic GMP Exercise Aged Oxidative metabolism business.industry Age Factors Skeletal muscle 030229 sport sciences Blood flow Cgmp signaling Adaptation Physiological Mitochondria Muscle medicine.anatomical_structure Endocrinology cGMP-specific phosphodiesterase type 5 business |
| Zdroj: | Journal of Applied Physiology. 124:109-117 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00634.2017 |
| Popis: | Physical activity has the potential to offset age-related impairments in the regulation of blood flow and O2 delivery to the exercising muscles; however, the mechanisms underlying this effect of physical activity remain poorly understood. The present study examined the role of cGMP in training-induced adaptations in the regulation of skeletal muscle blood flow and oxidative metabolism during exercise in aging humans. We measured leg hemodynamics and oxidative metabolism during exercise engaging the knee extensor muscles in young [ n = 15, 25 ± 1 (SE) yr] and older ( n = 15, 72 ± 1 yr) subjects before and after a period of aerobic high-intensity exercise training. To determine the role of cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, inhibition of PDE5 increased ( P < 0.05) skeletal muscle blood flow and O2 uptake during moderate-intensity exercise in the older group; however, these effects of PDE5 inhibition were not detected after training. These findings suggest a role for enhanced cGMP signaling in the training-induced improvement of regulation of blood flow in contracting skeletal muscle of older men. NEW & NOTEWORTHY The present study provides evidence for enhanced cyclic GMP signaling playing an essential role in the improved regulation of blood flow in contracting skeletal muscle of older men with aerobic exercise training. |
| Databáze: | OpenAIRE |
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