In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon
| Autor: | Jean Bickii, Pascal Ringwald, Leonardo K. Basco |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_treatment
Plasmodium falciparum MEFLOQUINE Dihydroartemisinin Amodiaquine Pharmacology Antimalarials Inhibitory Concentration 50 chemistry.chemical_compound Halofantrine Virology parasitic diseases ETUDE COMPARATIVE medicine Animals Humans HALOFANTRINE Cameroon Artemisinin PARASITE EXPERIMENTATION IN VITRO Quinine ACTIVITE BIOLOGIQUE biology Mefloquine MEDICAMENT PALUDISME biology.organism_classification Artemisinins DIHYDROARTEMISININ Infectious Diseases Pyrimethamine chemistry SENSIBILITE RESISTANCE Parasitology Sesquiterpenes medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 61:187-192 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1999.61.187 |
| Popis: | The in vitro activities of dihydroartemisinin (the biologically active metabolite of artemisinin derivatives), chloroquine, monodesethylamodiaquine (the biologically active metabolite of amodiaquine), quinine, mefloquine, halofantrine, and pyrimethamine were assessed in 65 African isolates of #Plasmodium falciparum$ from Yaoundé, Cameroon using an isotopic microtest. The 50% inhibitory concentration (IC50) values for dihydroartemisinin were within a narrow range from 0.25 to 4.56 nM, with a geometric mean of 1.11 nM (95% confidence interval = 0.96-1.28 nM). Dihydroartemisinin was equally active (P is greater than 0.05) against the chloroquine-sensitive isolates (geometric mean IC50 = 1.25 nM, 95% confidence interval = 0.99-1.57 nM) and the chloroquine-resistant isolates (geometric mean IC50 = 0.979 nM, 95% confidence interval = 0.816-1.18 nM). A significant positive correlation was observed between the responses to dihydroartemisinin and mefloquine (r = 0.662) or halofantrine (r = 0.284), suggesting in vitro cross-resistance. There was no correlation between the responses to dihydroartemisinin and other antimalarial drugs. (Résumé d'auteur) |
| Databáze: | OpenAIRE |
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