Successful treatment of calciphylaxis with bisphosphonates in kidney transplant recipients suffering from secondary hyperparathyroidism: A report of two cases
| Autor: | Man-Wai Lo, Kwok-Chi Lo, Lo-Yi Ho, Yuk-Yi Wong, Ping-Nam Wong, Kai-Chun Chan, Wing-Tung Kwok, Andrew K.M. Wong, Siu-Ka Mak, Kin-Yee Lo, Ho-Kwan Sin, Shuk-Fan Chan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:Surgery Case presentation 030230 surgery Kidney transplant Kidney transplantation 03 medical and health sciences 0302 clinical medicine Refractory medicine Bisphosphonate Adverse effect Transplantation Calciphylaxis business.industry Hyperparathyroidism lcsh:RD1-811 medicine.disease Optimal management Surgery 030211 gastroenterology & hepatology Secondary hyperparathyroidism business Persistent hyperparathyroidism |
| Zdroj: | Transplantation Reports, Vol 5, Iss 4, Pp 100068-(2020) |
| ISSN: | 2451-9596 |
| Popis: | Background The optimal management of calciphylaxis in kidney transplant recipients (KTRs) is uncertain. Case presentation We report 2 cases of refractory calciphylaxis in KTRs who suffered from persistent secondary hyperparathyroidism. They failed initial therapy with sodium thiosulphate but responded to treatment with bisphosphonates. No adverse events were noted with bisphosphonate therapy. Conclusion Bisphosphonates appear to be an effective therapy for KTRs with calciphylaxis who cannot tolerate or respond poorly to STS, particularly if they have persistent hyperparathyroidism post-transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|