Estimated global distribution and regional spread of HIV-1 genetic subtypes in the year 2000
| Autor: | José Esparza, Bernhard Schwardländer, Saladin Osmanov, Neff Walker, Claire Pattou |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Genotype Population HIV Infections Global Health Acquired immunodeficiency syndrome (AIDS) Pandemic Epidemiology medicine Prevalence Humans Pharmacology (medical) education Subtypes of HIV education.field_of_study Molecular epidemiology business.industry Incidence (epidemiology) Incidence virus diseases medicine.disease Virology Infectious Diseases Population Surveillance HIV-1 Molecular virology business Demography |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 29(2) |
| ISSN: | 1525-4135 |
| Popis: | The objective of this study was to estimate the global distribution and regional spread of different HIV-1 genetic subtypes and circulating recombinant forms (CRFs) in the year 2000. These estimates were made based on data derived from global HIV/AIDS surveillance and molecular virology studies. HIV-1 incidence during the year 2000 was estimated in defined geographic regions using a country-specific model developed by WHO-Joint UN Programmes on HIV/AIDS (UNAIDS). The proportion of new infections caused by different HIV-1 subtypes in the same geographic regions was estimated by experts from the WHO-UNAIDS Network for HIV Isolation and Characterization based on results generated by HIV molecular epidemiology studies in 1998-2000. The absolute numbers and relative proportions of new infections due to different genetic subtypes of HIV- 1 by different geographic regions were calculated using these two sets of estimated data. The results of the study demonstrated that the epidemiology of HIV-1 subtypes and CRFs is characterized by their differential distribution and varying significance as a driving cause of the pandemic on regional and global basis. The largest proportion of HIV-1 infections in the year 2000 was due to subtype C strains (47.2%). Subtype A/+CRF02_AG was estimated to be the second leading cause of the pandemic (27%) followed by subtype B strains (12.3%). The same analysis confirmed an increasing role of HIV-1 CRFs in the pandemic. The authors conclude that combined analysis of data based on the global HIV/AIDS surveillance and molecular virology studies provides for a useful model to monitor the dynamics of the global spread of HIV-1 subtypes and CRFs on regional and country levels--the information of potential importance for diagnosis and treatment of HIV/AIDS as well as for the development globally effective HIV vaccines. (authors) |
| Databáze: | OpenAIRE |
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