The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy
| Autor: | Josephine R. Chandler, Mohammad R. Seyedsayamdost, E. Peter Greenberg |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Burkholderia
Pharmaceutical Science Computational biology 01 natural sciences Article Analytical Chemistry Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Benzopyrans Pharmacology Bactobolin Biological Products Natural product Molecular Structure Burkholderia thailandensis biology 010405 organic chemistry Extramural Organic Chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Multigene Family Molecular targets Molecular Medicine Ribosomes |
| Zdroj: | J Nat Prod |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b01237 |
| Popis: | Bactobolin is a hybrid natural product with potent cytotoxic activity. Its production from Burkholderia thailandensis was reported as part of a collaboration between the Greenberg and Clardy laboratories in 2010. The collaboration sparked a series of studies leading to the discovery of new analogues and associated structure–activity relationships, the identification of the bactobolin biosynthetic gene cluster and assembly of its unusual amino acid building block, the molecular target of and resistance to the antibiotic, and finally an X-ray crystal structure of the ribosome– bactobolin complex. Herein, we review the collaborations that led to our current understanding of the chemistry and biology of bactobolin. |
| Databáze: | OpenAIRE |
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