Ventricular Expression and Circulating Levels of Immunoreactive Dynorphin in Heart Transplant Recipients
| Autor: | Nicholas D. Carter, B Whitehead, Art Ationu, Donald R. J. Singer, Keld Sorensen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Graft Rejection
Male Pathology medicine.medical_specialty Adolescent Heart Ventricles Radioimmunoassay Peptide Dynorphin Dynorphins Atrial natriuretic peptide Internal medicine Biopsy Blood plasma medicine Humans Child Receptor Endogenous opioid chemistry.chemical_classification medicine.diagnostic_test business.industry Hemodynamics Human heart General Medicine Endocrinology chemistry Heart Transplantation Female business |
| Zdroj: | Clinical Science. 85:1-4 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs0850001 |
| Popis: | 1. Dynorphin, an endogenous opioid peptide, acts on specific κ-opioid receptors in the rat heart for the local regulation of atrial natriuretic peptide release. No known study has examined the expression of dynorphin in the human heart. 2. In the present study a specific radioimmunoassay technique was used to determine ventricular expression of dynorphin at the peptide level in endomyocardial biopsy specimens and in plasma obtained from 13 heart transplant recipients. Ventricular biopsy specimens collected from 10 patients without cardiac complications during necropsy (less than 24 h from time of death) and plasma samples from 10 normal healthy subjects were used as controls. 3. The immunoreactive level of ventricular dynorphin was higher in heart transplant recipients (mean ± SEM 141 ± 32 pg/mg of soluble protein, range 7–573 pg/mg of soluble protein, P 4. These results show that immunoreactive levels of dynorphin in plasma and ventricle are increased after heart transplantation, suggesting a possible pathophysiological role for dynorphin in the heart. |
| Databáze: | OpenAIRE |
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