Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp
| Autor: | Leon Kaysan, Marc Stadler, Benjarong Thongbai, Frank Surup, Birthe Sandargo, Rémy Bertrand Teponno, Christian Richter |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Science Antibiotics 01 natural sciences Marasmius antibiotics marasmius Microbiology QD241-441 carotane medicine Cytotoxicity biology 010405 organic chemistry Chemistry basidiomycota Organic Chemistry sesquiterpenoid Basidiomycota biology.organism_classification Isolation (microbiology) 0104 chemical sciences 010404 medicinal & biomolecular chemistry fulvoferruginin Marasmius sp Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1385-1391 (2021) |
| ISSN: | 1860-5397 |
| DOI: | 10.3762/bjoc.17.97 |
| Popis: | A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (1), fulvoferruginins B–F (2–6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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