Amplitude of low-frequency fluctuation may be an early predictor of delayed motor development due to neonatal hyperbilirubinemia: a fMRI study
| Autor: | Chengxiang Lin, Feifan Xiao, Liping Wang, Chunmei Lu, Jian Zhou, Wenhao Zhou, Zhongwei Qiao, Yu-Wei Jiang, Guoqiang Cheng, Dajiang Zhang, Kai Yan, Haowei Yang, Junbo Wang, Yanting Kong, Yong Zhang, Qian Qin |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lung Imaging biomarker medicine.diagnostic_test business.industry Brain damage medicine.disease 03 medical and health sciences Pneumonia 0302 clinical medicine medicine.anatomical_structure 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health Basal ganglia medicine Cardiology Kernicterus Original Article medicine.symptom Prospective cohort study business Functional magnetic resonance imaging human activities 030217 neurology & neurosurgery |
| Zdroj: | Transl Pediatr |
| ISSN: | 2224-4344 2224-4336 |
| DOI: | 10.21037/tp-20-447 |
| Popis: | BACKGROUND: Acute bilirubin encephalopathy or kernicterus is the worst consequence of brain damage caused by the elevation of total unbound serum bilirubin (TSB) in neonates. The present study aimed to visualize the characteristic brain regions of neonates with hyperbilirubinemia (HB) using functional magnetic resonance imaging (fMRI) and to measure the amplitude of low-frequency fluctuation (ALFF) values. METHODS: This was a prospective cohort study, which included newborns with HB who were hospitalized at the Children’s Hospital of Fudan University. The control group included neonates admitted with neonatal simple wet lung or pneumonia without neurological disease or brain injury. Newborns were divided into a severe hyperbilirubinemia group (SHB), moderate HB group, and control group based on TSB levels. The newborns completed routine MRI combined with fMRI scans and brainstem auditory evoked potentials (BAEPs) during their hospitalization. RESULTS: A total of 251 newborns were included in this study. There were 45 patients in the SHB group, 65 in the HB group, and 141 in the control group. The average ALFF value in the basal ganglia region in the SHB group was the highest, which was greater than that in the HB and control groups (P |
| Databáze: | OpenAIRE |
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