Parental Whole Life Cycle Exposure to Dietary Methylmercury in Zebrafish (Danio rerio) Affects the Behavior of Offspring
| Autor: | Jessica A. Head, Rebekah H. Klingler, Francisco X. Mora-Zamorano, Cheryl A. Murphy, Michael J. Carvan, Niladri Basu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Offspring Foraging Danio Zoology 010501 environmental sciences 01 natural sciences Locomotor activity Predation Toxicology 03 medical and health sciences chemistry.chemical_compound Animals Environmental Chemistry Methylmercury Zebrafish Swimming 0105 earth and related environmental sciences Behavior Animal biology General Chemistry Methylmercury Compounds biology.organism_classification Diet 030104 developmental biology Behavioral test chemistry |
| Zdroj: | Environmental Science & Technology. 50:4808-4816 |
| ISSN: | 1520-5851 0013-936X |
| DOI: | 10.1021/acs.est.6b00223 |
| Popis: | Methylmercury (MeHg) is an established neurotoxicant of concern to fish-eating organisms. While most studies have focused on the fish consumers, much less is known about the effects of MeHg on the fish themselves, especially following exposures to chronic and environmentally relevant scenarios. Here we evaluated the behavioral effects of developmental MeHg insult by exposing parental generations of zebrafish to an environmentally realistic MeHg dietary concentration (1 ppm) and two higher concentrations (3 and 10 ppm) throughout their whole life span. Upon reaching adulthood, their offspring were analyzed through a series of behavioral tests, including the visual-motor response (VMR) assay, analysis of spontaneous swimming and evaluation of foraging efficiency. The VMR assay identified decreased locomotor output in the 6 day postfertilization (dpf) offspring of fish exposed to 3 and 10 ppm MeHg. However, in a second test 7 dpf fish revealed an increase in locomotor activity in all MeHg exposures tested. Increases in locomotion continued to be observed until 16 dpf, which coincided with increased foraging efficiency. These results suggest an association between MeHg and hyperactivity, and imply that fish chronically exposed to MeHg in the wild may be vulnerable to predation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|