Muscle endothelial-dependent microvascular dysfunction in adulthood due to early postnatal overnutrition
| Autor: | Pierre Nivoit, Fatima Z. G. A. Cyrino, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar, Richard Diego Leite, Beatriz C. S. Boa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Intra-Abdominal Fat Litter Size Adipose tissue Biology Weight Gain Biochemistry chemistry.chemical_compound Overnutrition Internal medicine Cricetinae medicine Animals Body Size Humans Obesity Muscle Skeletal medicine.diagnostic_test Mesocricetus Cell Biology medicine.disease Arterioles Endocrinology chemistry Adipose Tissue Low-density lipoprotein Cremaster muscle Female Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine Lipid profile Weight gain |
| Zdroj: | Microvascular research. 84(1) |
| ISSN: | 1095-9319 |
| Popis: | The aims of our study were to investigate effects of postnatal overnutrition, obtained by restricting the number of pups per litter, on microcirculatory reactivity, fat depots, its total percentage and lipid profile. Microvascular reactivity was evaluated in the cremaster muscle of 24 hamsters divided into four groups, with 6 animals in each one: normal (NL) and restricted (RL) litter groups, both at 6th and 21st weeks of age. The NL group had 8-9 pups and the RL 3 pups per litter and to avoid the litter effect, only one animal was used per litter. The results have shown that the RL group had higher velocity of weight, body mass and fat gain compared to the NL one at weeks 6 and 21. Significant differences were also observed on urogenital fat depot, total cholesterol and low density lipoprotein between groups. At the lowest concentration of Ach, the RL group showed smaller arteriolar dilatation at the 21st than at the 6th week [5(3-13) vs 19(8-40)%, p |
| Databáze: | OpenAIRE |
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