The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity
| Autor: | Ghada Boghdadi, Enas I. Mohamed, Omyma Zakaria, Enass A. Elewa |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Proteinuria business.industry Disease activity (SLEDAI) Lupus nephritis Interleukin medicine.disease Gastroenterology Systemic Lupus Erythematosus Pyuria Proinflammatory cytokine Rheumatology immune system diseases Internal medicine medicine Cytokines Interferon gamma Interleukin 17 medicine.symptom business skin and connective tissue diseases medicine.drug Anti-SSA/Ro autoantibodies |
| Zdroj: | The Egyptian Rheumatologist. (1):21-27 |
| ISSN: | 1110-1164 |
| DOI: | 10.1016/j.ejr.2013.10.003 |
| Popis: | Aim of the work This work was designed to study the production of proinflammatory cytokines in SLE patients and their correlation with disease activity and study if they can be used as biomarkers for renal activity in lupus nephritis patients. Patients and methods This study was carried out on 70 subjects divided into two groups: Group I (SLE group) which included 40 SLE patients and Group II (Control group) which included 30 apparently healthy controls. The patients were subjected to full history taking and complete clinical examination. Assessment of disease activity in SLE patients by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Sera of patients and controls were screened for the level of cytokine expression of T helper cells including interleukin 17 (IL-17), interleukin 4 (IL-4) and interferon gamma (IFN-γ). Results Serum levels of IL-4 were significantly lower while both IL-17 and IFN-γ were significantly higher in SLE patients than in the control group. The most powerful predictor and correlated cytokine with the SLEDAI in SLE patients was IL-17. Higher serum level of IFN-γ was associated with more pyuria and hematuria, while higher IL-17 was associated with more pyuria and proteinuria in SLE patients. Conclusion The serum level of IL-17 and IFN-γ was proven to be significantly higher in SLE patients and can be used as biomarkers of renal activity. |
| Databáze: | OpenAIRE |
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