Qualitative parameters of the colonic flora in Patients with HNF1A-MODY are different from those observed in type 2 diabetes mellitus
| Autor: | Maciej T. Malecki, Tomasz Gosiewski, Małgorzata Bulanda, Iwona Trznadel Morawska, Paweł Wołkow, Dominika Salamon, Bartłomiej Matejko, Agnieszka Ludwig-Gałęzowska, Magdalena Szopa, Piotr Radkowski, Tomasz Klupa, Przemysław Kapusta, Sandra Mrozinska, Agnieszka Sroka-Oleksiak |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Flora endocrine system diseases Article Subject Colon Endocrinology Diabetes and Metabolism 030106 microbiology Physiology Type 2 diabetes Biology lcsh:Diseases of the endocrine glands. Clinical endocrinology Maturity onset diabetes of the young 03 medical and health sciences Endocrinology RNA Ribosomal 16S Proteobacteria medicine Humans Phylogeny Feces lcsh:RC648-665 Bacteroidetes Ecology nutritional and metabolic diseases Type 2 Diabetes Mellitus Middle Aged medicine.disease biology.organism_classification Obesity Bacterial Typing Techniques Gastrointestinal Microbiome HNF1A Diabetes Mellitus Type 2 Case-Control Studies Female Research Article |
| Zdroj: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2016 (2016) |
| Popis: | Background. Type 2 diabetes mellitus (T2DM) is determined by genetic and environmental factors. There have been many studies on the relationship between the composition of the gastrointestinal bacterial flora, T2DM, and obesity. There are no data, however, on the gut microbiome structure in monogenic forms of the disease including Maturity Onset Diabetes of the Young (MODY).Methods. The aim of the investigation was to compare the qualitative parameters of the colonic flora in patients with HNF1A-MODY and T2DM and healthy individuals. 16S sequencing of bacterial DNA isolated from the collected fecal samples using the MiSeq platform was performed.Results. There were significant between-group differences in the bacterial profile. At the phylum level, the amount of Proteobacteria was higher (p=0.0006) and the amount of Bacteroidetes was lower (p=0.0005) in T2DM group in comparison to the control group. In HNF1A-MODY group, the frequency of Bacteroidetes was lower than in the control group (p=0.0143). At the order level, Turicibacterales was more abundant in HNF1A-MODY group than in T2DM group.Conclusions. It appears that there are differences in the gut microbiome composition between patients with HNF1A-MODY and type 2 diabetes. Further investigation on this matter should be conducted. |
| Databáze: | OpenAIRE |
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